A Bayesian design for phase II clinical trials with delayed responses based on multiple imputation.

@article{Cai2014ABD,
  title={A Bayesian design for phase II clinical trials with delayed responses based on multiple imputation.},
  author={Chunyan Cai and Suyu Liu and Ying Yuan},
  journal={Statistics in medicine},
  year={2014},
  volume={33 23},
  pages={4017-28}
}
Interim monitoring is routinely conducted in phase II clinical trials to terminate the trial early if the experimental treatment is futile. Interim monitoring requires that patients' responses be ascertained shortly after the initiation of treatment so that the outcomes are known by the time the interim decision must be made. However, in some cases… CONTINUE READING