A Bayesian Approach to the Evolution of Metabolic Networks on a Phylogeny

@inproceedings{Mithani2010ABA,
  title={A Bayesian Approach to the Evolution of Metabolic Networks on a Phylogeny},
  author={Aziz Mithani and Gail M. Preston and Jotun Hein},
  booktitle={PLoS Computational Biology},
  year={2010}
}
The availability of genomes of many closely related bacteria with diverse metabolic capabilities offers the possibility of tracing metabolic evolution on a phylogeny relating the genomes to understand the evolutionary processes and constraints that affect the evolution of metabolic networks. Using simple (independent loss/gain of reactions) or complex (incorporating dependencies among reactions) stochastic models of metabolic evolution, it is possible to study how metabolic networks evolve over… CONTINUE READING
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