A Balance between Secreted Inhibitors and Edge Sensing Controls Gastruloid Self-Organization.

Abstract

The earliest aspects of human embryogenesis remain mysterious. To model patterning events in the human embryo, we used colonies of human embryonic stem cells (hESCs) grown on micropatterned substrate and differentiated with BMP4. These gastruloids recapitulate the embryonic arrangement of the mammalian germ layers and provide an assay to assess the… (More)
DOI: 10.1016/j.devcel.2016.09.016

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