A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone

@inproceedings{Song2017ABT,
  title={A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone},
  author={Ok-Ryul Song and Han-Byul Kim and Samuel Jouny and Isabelle Ricard and Alexandre Vandeputte and Nathalie Deboosere and Estelle Marion and Christophe J. Queval and Pierre Lesport and Emmanuel Bourinet and Daniel Henrion and Seog Bae Oh and Guillaume Lebon and Guillaume Sandoz and Edouard Yeramian and Laurent Marsollier and Priscille Brodin},
  booktitle={Toxins},
  year={2017}
}
Mycolactone, a polyketide molecule produced by Mycobacterium ulcerans, is the etiological agent of Buruli ulcer. This lipid toxin is endowed with pleiotropic effects, presents cytotoxic effects at high doses, and notably plays a pivotal role in host response upon colonization by the bacillus. Most remarkably, mycolactone displays intriguing analgesic capabilities: the toxin suppresses or alleviates the pain of the skin lesions it inflicts. We demonstrated that the analgesic capability of… CONTINUE READING

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Mentioned Connections BETA
AnalgesicsNo subtypePain
Most remarkably , mycolactone displays intriguing analgesic capabilities : the toxin suppresses or alleviates the pain of the skin lesions it inflicts .
AnalgesicsIs related toPain
Most remarkably , mycolactone displays intriguing analgesic capabilities : the toxin suppresses or alleviates the pain of the skin lesions it inflicts .
PainIs related toAnalgesics
Most remarkably , mycolactone displays intriguing analgesic capabilities : the toxin suppresses or alleviates the pain of the skin lesions it inflicts .
PainNo subtypeAnalgesics
Most remarkably , mycolactone displays intriguing analgesic capabilities : the toxin suppresses or alleviates the pain of the skin lesions it inflicts .
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