A BRCA1/2 mutation, high breast density and prominent pushing margins of a tumor independently contribute to a frequent false-negative mammography.

@article{TilanusLinthorst2002ABM,
  title={A BRCA1/2 mutation, high breast density and prominent pushing margins of a tumor independently contribute to a frequent false-negative mammography.},
  author={Madeleine M. A. Tilanus-Linthorst and Leon C. Verhoog and I. M. Obdeijn and Karina C.M. Bartels and Marian Menke-Pluymers and A. M. M. Eggermont and Jan Klijn and Hanne Meijers-Heijboer and Theo van der Kwast and Cecile T. M. Brekelmans},
  journal={International journal of cancer},
  year={2002},
  volume={102 1},
  pages={91-5}
}
Female BRCA1/2 mutation carriers develop in up to 50% breast cancer (BC) before age 50 years. We investigated whether the specific histologic features of BRCA1/2-associated breast cancer influence imaging. We correlated the mammographic results with the histology of 34 BC in BRCA1/2 mutation carriers and 34 sporadic cancers in patients, matched for age and year of diagnosis. Mammography was significantly more frequently false-negative in carriers than controls (62% vs. 29% p = 0.01), despite… CONTINUE READING