A BDNF autocrine loop in adult sensory neurons prevents cell death

  title={A BDNF autocrine loop in adult sensory neurons prevents cell death},
  author={Ann L. Acheson and Joanne C Conover and James P. Fandl and Thomas M. Dechiara and Michelle Russell and Anupriya Thadani and Stephen P. Squinto and George D. Yancopoulos and Ronald M. Lindsay},
DURING the initial phase of their development, sensory neurons of the dorsal root ganglion (DRG) require target-derived trophic support for their survival1–3, but as they mature they lose this requirement. Because many of these neurons express BDNF (brain-derived neurotrophic factor) messenger RNA4,5, we hypo-thesized that BDNF might act as an autocrine survival factor in adult DRG neurons, thus explaining their lack of dependence on exogenous growth factors. When cultured adult DRG cells were… 
TrkB expression and early sensory neuron survival are independent of endogenous BDNF
These studies of sensory neuron development in BDNF‐deficient embryos have demonstrated that endogenous BDNF is neither required for the early survival of these neurons nor for the induction of TrkB expression.
Non target-derived roles of the neurotrophins.
  • A. Acheson, R. Lindsay
  • Biology
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 1996
The BDNF autocrine loop that is proposed to be present in sensory neurons may be representative of a broader phenomenon in the nervous system as a whole, where the balance of neurotrophic support may shift during development from target-derived to paracrine or autocrine modes.
Factors contributing to adult DRG neurotrophin-independent neuronal survival
The use of pharmacological inhibitors of cellular signalling pathways confirmed the importance of the phosphoinositide kinase-3 (PI 3-K) and protein kinase C (PKC) pathways in this neurotrophin-independent neuronal survival.
The Survival-Promoting Effect of Glial Cell Line-Derived Neurotrophic Factor on Axotomized Corticospinal Neurons In Vivo Is Mediated by an Endogenous Brain-Derived Neurotrophic Factor Mechanism
It is shown that the rescuing by GDNF requires the presence of endogenous cortical BDNF, implicating a central role of this neurotrophin in the trophic support of axotomized CSNs and a troPHic cross-talk between BDNF and GDNF regarding the maintenance of lesioned CSNs.
Autocrine Action of BDNF on Dendrite Development of Adult-Born Hippocampal Neurons
BDNF expressed in adult-born GCs plays a critical role in dendrite development by acting as an autocrine factor and was required for the development of normal density of spines and normal percentage of sp spine containing the postsynaptic marker PSD-95, suggesting autocrine BDNF regulation of synaptogenesis.


BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra
BRAIN-derived neurotrophic factor seems to be a trophic factor for mesencephalic dopaminergic neurons, increasing their survival, including that of neuronal cells which degenerate in Parkinson's disease.
Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons
  • R. Lindsay
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1988
It is found that adult rat dorsal root ganglion sensory neurons are not dependent on NGF or other survival factors for long-term maintenance in vitro, and both NGF and brain-derived neurotrophic factor (BDNF) were found to stimulate the regeneration of axons from adult DRG neurons.
Mice lacking brain-derived neurotrophic factor develop with sensory deficits
It is shown that mutant mice lacking BDNF have severe deficiencies in coordination and balance, associated with excessive degeneration in several sensory ganglia including the vestibular ganglion, and that BDNF is required for the survival and target innervation of particular neuronal populations.
Coexpression of neurotrophins and their receptors in neurons of the central nervous system.
The results show that individual neurons of the central nervous system can coexpress neurotrophins and their receptors and produce two neurotrophic factors, which could support neuronal survival after brain insults, not only via retrograde transport but also through autocrine mechanisms.
Central nervous system and peripheral nerve growth factor provide trophic support critical to mature sensory neuronal survival
The results indicate that sensory neurones are maintained by the trophic support provided by both peripheral and central targets, mediated by NGF and other as yet unidentified troPHic factors.