A BC200-derived element and Z-DNA as structural markers in annexin I genes: Relevance to Alu evolution and annexin tetrad formation

@article{Morgan1995ABE,
  title={A BC200-derived element and Z-DNA as structural markers in annexin I genes: Relevance to Alu evolution and annexin tetrad formation},
  author={Reginald O Morgan and Mar{\'i}a Pilar Felipe Fern{\'a}ndez},
  journal={Journal of Molecular Evolution},
  year={1995},
  volume={41},
  pages={979-985}
}
We have identified two types of structural elements in genomic DNA for annexin I that provide physical evidence of genetic events leading to conserved changes in gene structure. The sequence upstream of the transcribed region in human annexin I contained a rare, Alu-like repetitive element with flanking direct repeats, probably derived from the active BC200 gene via germline retroposition. Nucleotide substitutions in this BC200 insert relative to the 7SL gene and its absence in rodent annexins… CONTINUE READING

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