A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress.

Abstract

Molecular chaperones regulate quality control in the human proteome, pathways that have been implicated in many diseases, including heart failure. Mutations in the BAG3 gene, which encodes a co-chaperone protein, have been associated with heart failure due to both inherited and sporadic dilated cardiomyopathy. Familial BAG3 mutations are autosomal dominant… (More)
DOI: 10.1172/jci.insight.94623

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@article{Judge2017ABC, title={A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress.}, author={Luke M. Judge and Juan A Perez-Bermejo and Annie Truong and Alexandre Js Ribeiro and Jennie C Yoo and Christina L Jensen and Mohammad A. Mandegar and Nathaniel D Huebsch and Robyn M. Kaake and P K So and Deepak Srivastava and Beth L. Pruitt and Nevan J. Krogan and Bruce R. Conklin}, journal={JCI insight}, year={2017}, volume={2 14} }