A BAF-centred view of the immune system

  title={A BAF-centred view of the immune system},
  author={Tian H. Chi},
  journal={Nature Reviews Immunology},
Chromatin structure dictates whether DNA templates are accessible to nuclear proteins; therefore, it is tightly regulated. To reconfigure chromatin, cells often mobilize 'chromatin-remodelling complexes' that use energy to disrupt histone–DNA contacts. BAF complexes, which are related to the yeast SWI–SNF complex, are the prototypical mammalian chromatin-remodelling complexes. In the past few years, studies have revealed the crucial and diverse roles of BAF complexes in the regulation of the… CONTINUE READING

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