A 90-day study of subchronic oral toxicity of 20 nm, negatively charged zinc oxide nanoparticles in Sprague Dawley rats.

@article{Park2014A9S,
  title={A 90-day study of subchronic oral toxicity of 20 nm, negatively charged zinc oxide nanoparticles in Sprague Dawley rats.},
  author={Hark-Soo Park and Sung-Sup Shin and Eun Ho Meang and Jeong-sup Hong and Jong-Il Park and Su-Hyon Kim and Sang-Bum Koh and Seung-Young Lee and Dong-Hyouk Jang and Jong-Yun Lee and Yle-Shik Sun and Jin Seok Kang and Yu-Ri Kim and Meyoung-kon Kim and Jayoung Jeong and Jong-Kwon Lee and Woo-Chan Son and J S Park},
  journal={International journal of nanomedicine},
  year={2014},
  volume={9 Suppl 2},
  pages={
          79-92
        }
}
PURPOSE The widespread use of nanoparticles (NPs) in industrial and biomedical applications has prompted growing concern regarding their potential toxicity and impact on human health. This study therefore investigated the subchronic, systemic oral toxicity and no-observed-adverse-effect level (NOAEL) of 20 nm, negatively charged zinc oxide (ZnO(SM20(-))) NPs in Sprague Dawley rats for 90 days. METHODS The high-dose NP level was set at 500 mg/kg of bodyweight, and the mid- and low-dose levels… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-3 of 3 citations