A 90-day study of sub-chronic oral toxicity of 20 nm positively charged zinc oxide nanoparticles in Sprague Dawley rats

@inproceedings{Park2014A9S,
  title={A 90-day study of sub-chronic oral toxicity of 20 nm positively charged zinc oxide nanoparticles in Sprague Dawley rats},
  author={Hark-Soo Park and S. Kim and Taekjin Lee and Geon-Yong Kim and EunHo Meang and Jeong-sup Hong and Su-Hyon Kim and Sang-Bum Koh and Seung-Guk Hong and Yle-Shik Sun and Jin Seok Kang and Yu-Ri Kim and Meyoung-kon Kim and Jayoung Jeong and Jong-Kwon Lee and Woo-Chan Son and Jae-Hak Park},
  booktitle={International journal of nanomedicine},
  year={2014}
}
PURPOSE The study reported here was conducted to determine the systemic oral toxicity and to find the no-observed-adverse-effect level of 20 nm positively charged zinc oxide (ZnO(SM20(+))) nanoparticles in Sprague Dawley rats for 90 days. METHODS For the 90-day toxicity study, the high dose was set as 500 mg per kg of body weight (mg/kg) and the middle and low dose were set to 250 mg/kg and 125 mg/kg, respectively. The rats were held for a 14-day recovery period after the last administration… CONTINUE READING