A 90 kDa fragment of filamin A promotes Casodex-induced growth inhibition in Casodex-resistant androgen receptor positive C4-2 prostate cancer cells

@article{Wang2007A9K,
  title={A 90 kDa fragment of filamin A promotes Casodex-induced growth inhibition in Casodex-resistant androgen receptor positive C4-2 prostate cancer cells},
  author={Yufen Wang and Jeffrey I. Kreisberg and Roble G. Bedolla and Margarita Mikhailova and Ralph W. deVere White and Paramita M Ghosh},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={6061-6070}
}
Prostate tumors are initially dependent on androgens for growth, but the majority of patients treated with anti-androgen therapy progress to androgen-independence characterized by resistance to such treatment. This study investigates a novel role for filamin A (FlnA), a 280 kDa cytoskeletal protein (consisting of an actin-binding domain (ABD) followed by 24 sequential repeats), in androgen-independent (AI) growth. Full-length FlnA is cleaved to 170 kDa (ABD+FlnA1–15) and 110 kDa fragments… CONTINUE READING

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