A 9 Å Resolution X-Ray Crystallographic Map of the Large Ribosomal Subunit

  title={A 9 {\AA} Resolution X-Ray Crystallographic Map of the Large Ribosomal Subunit},
  author={Nenad Ban and Betty Freeborn and Poul Nissen and Pawel Penczek and Robert A. Grassucci and Robert C Sweet and Joachim Frank and Peter B Moore and Thomas A Steitz},
The 50S subunit of the ribosome catalyzes the peptidyl-transferase reaction of protein synthesis. We have generated X-ray crystallographic electron density maps of the large ribosomal subunit from Haloarcula marismortui at various resolutions up to 9 A using data from crystals that diffract to 3 A. Positioning a 20 A resolution EM image of these particles in the crystal lattice produced phases accurate enough to locate the bound heavy atoms in three derivatives using difference Fourier maps… CONTINUE READING
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