A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand.

Abstract

The in vitro pharmacological properties of a novel cholinergic channel ligand, A-85380 [3-(2(S)-azetidinylmethoxy)pyridine], were examined using tissue preparations that express different putative nAChR subtypes. In radioligand binding studies, A-85380 is shown to be a potent and selective ligand for the human alpha 4 beta 2 nAChR subtype (Ki = 0.05 + 0.01… (More)

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@article{Sullivan1996A85380P, title={A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand.}, author={James P Sullivan and D L Donnelly-roberts and Clark Briggs and David J. Anderson and Murali Gopalakrishnan and M Piattoni-Kaplan and Jeffrey E. Campbell and David G McKenna and Eduardo J Molinari and Andrea M Hettinger and David S. Garvey and J T Wasicak and Mark W. Holladay and Mark Williams and Stephen P. Arneri{\'c}}, journal={Neuropharmacology}, year={1996}, volume={35 6}, pages={725-34} }