A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey

  title={A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey},
  author={K. Asin and L. Bednarz and A. Nikkel and P. Gore and A. Nadzan},
  journal={Pharmacology Biochemistry and Behavior},
  • K. Asin, L. Bednarz, +2 authors A. Nadzan
  • Published 1992
  • Biology, Medicine
  • Pharmacology Biochemistry and Behavior
  • The anorectic actions of cholecystokinin (CCK)-8 and of a selective CCK-A agonist, A-71623, were examined in CD1 mice, beagle dogs, and cynomolgus monkeys. A-71623 suppressed intakes in all species tested, and the effects were blocked by a selective CCK-A antagonist, A-70104. In the dog only, CCK-8 was more potent on a molar basis compared to A-71623, although the effects of both CCK agonists were more short-lived in the dog compared to the other species tested. Our results support other… CONTINUE READING
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