A 7-nitrobenz-2-oxa-1,3-diazole based highly sensitive and selective turn-on chemosensor for copper(II) ion with intracellular application without cytotoxicity.

@article{Mistri2013A7B,
  title={A 7-nitrobenz-2-oxa-1,3-diazole based highly sensitive and selective turn-on chemosensor for copper(II) ion with intracellular application without cytotoxicity.},
  author={Tarun Mistri and Rabiul Alam and Malay Dolai and S. K. Mandal and Anisur Rahman Khuda-Bukhsh and Mahammad Ali},
  journal={Organic \& biomolecular chemistry},
  year={2013},
  volume={11 9},
  pages={
          1563-9
        }
}
A 7-nitrobenz-2-oxa-1,3-diazole (NBD) derived turn-on fluorescent probe (1) exhibits a reversible binding to Cu(2+) ion in presence of other metal ions, giving ~20 fold increase in fluorescence intensity. The apparent association constant (K(a)) for Cu(2+) was found to be 2.62 × 10(4) M(-1). The intracellular Cu(2+) imaging behaviour of chemosensor 1 on HeLa cells studied by fluorescence microscopy revealed that after incubation with 1 cells exhibited intensive fluorescence when exogenous Cu(2… 
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30 Citations

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