A-69024: a non-benzazepine antagonist with selectivity for the dopamine D-1 receptor.

@article{Kerkman1989A69024AN,
  title={A-69024: a non-benzazepine antagonist with selectivity for the dopamine D-1 receptor.},
  author={Daniel Kerkman and Michele Ackerman and Linda D. Artman and Robert G Mackenzie and M. Catherine Johnson and Lisa Bednarz and W. E. Montana and Karen E. Asin and H F Stampfli and John W. Kebabian},
  journal={European journal of pharmacology},
  year={1989},
  volume={166 3},
  pages={481-91}
}
A-69024 HBr, 1-(2-bromo-4,5-dimethoxybenzyl)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4- tetrahydroisoquinoline hydrobromide, is a selective antagonist of the dopamine D-1 receptor. A-69024 HBr shows an apparent affinity toward the D-1 receptor (identified using [125I]SCH 23390) of 12.6 (4.15-38.3) nM (mean (90% CL), n = 3); the apparent affinity toward the D-2 receptor (identified using [3H]spiroperidol is 1 290 (1,200-1,380) nM (n = 3); using [125I]lysergic acid diethylamine to identify the 5-HT1C… CONTINUE READING

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