A 68930 and dihydrexidine inhibit locomotor activity and d-amphetamine-induced hyperactivity in rats: a role of inhibitory dopamine d1/5 receptors in the prefrontal cortex?

@article{Isacson2004A6A,
  title={A 68930 and dihydrexidine inhibit locomotor activity and d-amphetamine-induced hyperactivity in rats: a role of inhibitory dopamine d1/5 receptors in the prefrontal cortex?},
  author={R. Isacson and B. Kull and C. Wahlestedt and P. Salmi},
  journal={Neuroscience},
  year={2004},
  volume={124},
  pages={33-42}
}
  • R. Isacson, B. Kull, +1 author P. Salmi
  • Published 2004
  • Biology, Medicine
  • Neuroscience
  • The behavioral and biochemical effects of the full dopamine D(1/5) receptor agonists, dihydrexidine and (1R,3S)-1-aminomethyl-5,6-dihydroxy-3-phenylisochroman HCl (A 68930), were examined in rats. Both A 68930 (0-4.6 mg kg(-1), s.c.) and dihydrexidine (0-8.0 mg kg(-1), s.c.) caused a dose-dependent suppression of locomotor activity, as assessed in an open-field. This locomotor suppression was dose-dependently antagonized by the selective dopamine D(1/5) receptor antagonist R(+)-7-chloro-8… CONTINUE READING
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    • 2006
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