A 50 kilodalton protein associated with raf and pp60(v-src) protein kinases is a mammalian homolog of the cell cycle control protein cdc37.

@article{Perdew1997A5K,
  title={A 50 kilodalton protein associated with raf and pp60(v-src) protein kinases is a mammalian homolog of the cell cycle control protein cdc37.},
  author={Gary H. Perdew and Herbert Wiegand and John Patrick Vanden Heuvel and Carter Mitchell and S. Swetha Singh},
  journal={Biochemistry},
  year={1997},
  volume={36 12},
  pages={3600-7}
}
Several oncogenic protein kinases including c-raf-1 and pp60(v-src) are known to directly interact with the 90 kDa heat shock protein (hsp90)/p50 complexes. Using a monoclonal antibody to detect p50 during a purification scheme, p50 was purified to homogeneity. Internal amino acid sequence information was obtained and used to clone a partial cDNA. Comparison of the p50 sequence to other cloned proteins revealed 89% homology with a glycosaminoglycan-binding protein and 54% homology with… CONTINUE READING

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