A 5-hydroxyoxindole derivative attenuates LPS-induced inflammatory responses by activating the p38-Nrf2 signaling axis.

@article{Niino2018A5D,
  title={A 5-hydroxyoxindole derivative attenuates LPS-induced inflammatory responses by activating the p38-Nrf2 signaling axis.},
  author={Tomomi Niino and Kenji Tago and Daisuke Yasuda and Kyoko C Takahashi and Tadahiko Mashino and Hiroomi Tamura and Megumi Funakoshi-Tago},
  journal={Biochemical pharmacology},
  year={2018},
  volume={155},
  pages={
          182-197
        }
}
5-Hydroxyoxindole is a urinary metabolite of indole that exhibits antioxidant activity. In the present study, we found that a 5-hydroxyoxindole derivative (5-HI) significantly inhibited LPS-induced inflammatory effects in the murine macrophage cell line, RAW264.7. 5-HI induced the expression of the transcription factor, Nrf2, which is typically… CONTINUE READING