A 5′-flanking region polymorphism in toll-like receptor 4 is associated with gastric cancer in a Chinese population☆

@inproceedings{Huang2010A5R,
  title={A 5′-flanking region polymorphism in toll-like receptor 4 is associated with gastric cancer in a Chinese population☆},
  author={Hua Huang and Juan Wu and Guangfu Jin and Hanze Zhang and Yanbing Ding and Zhaolai Hua and Yan Zhou and Yan Xue and Yan Lu and Zhibin Hu and Yaochu Xu and Hongbing Shen},
  booktitle={Journal of biomedical research},
  year={2010}
}
OBJECTIVE Inflammation induced by H.pylori colonization in the stomach is related to the development of gastric cancer and the genetic variations of the genes involved in the immune responses modify the host response to the infection. The aim of this study was to evaluate whether polymorphisms in the toll-like receptor 4 (TLR4) gene, a key regulator of both innate and adaptive immunity, were related to the susceptibility to gastric cancer in a Chinese population. METHODS Two variations in the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

TLR4 Polymorphisms and Expression in Solid Cancers

  • Molecular Diagnosis & Therapy
  • 2018
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 26 REFERENCES

Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kappa B activation and chemokine e x p re s s i o n b y ep i th e l i a l c e l l s

MF Smith, Jr., +4 authors K Ryan
  • J B io l Ch e m 2003;278:32552-60
  • 2003
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

David A. Schwartz, Nancy C. Arbour, +6 authors Janet L. Watt
  • Nature Genetics
  • 2000
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Functional Consequences of Toll-like Receptor 4 Polymorphisms

Bart Ferwerda, Matthew BB McCall, +4 authors Mihai G Netea
  • Molecular medicine
  • 2008
VIEW 1 EXCERPT