A 5′-CG-3′-rich region in the promoter of the transcriptionally frequently silenced RET protooncogene lacks methylated cytidine residues

@article{Munnes1998A5R,
  title={A 5′-CG-3′-rich region in the promoter of the transcriptionally frequently silenced RET protooncogene lacks methylated cytidine residues},
  author={Marc Munnes and Giovanna Patrone and Birgit Schmitz and Giovanni Romeo and Walter Doerfler},
  journal={Oncogene},
  year={1998},
  volume={17},
  pages={2573-2583}
}
In a large proportion of familial and sporadic cases of Hirschsprung disease (HSCR) mutations in the RET (rearranged during transfection) protooncogene have been described. We have investigated the structure of the RET gene promoter and have analysed a region of approximately 1000 nucleotides in its promoter and 5′-upstream segments for the occurrence of 5-methyldeoxy-cytidine (5-mC) residues by using the bisulfite protocol of the genomic sequencing method. With an estimated sensitivity of… CONTINUE READING