A-412997 is a selective dopamine D4 receptor agonist in rats

@article{Moreland2005A412997IA,
  title={A-412997 is a selective dopamine D4 receptor agonist in rats},
  author={Robert B. Moreland and Meena V. Patel and Gin C. Hsieh and Jill M. Wetter and Kennan Marsh and Jorge D. Brioni},
  journal={Pharmacology Biochemistry and Behavior},
  year={2005},
  volume={82},
  pages={140-147}
}
A-412997 (2-(3',4',5',6'-tetrahydro-2'H-[2,4'] bipyridinyl-1'-yl)-N-m-tolyl-acetamide) is a highly selective dopamine D4 receptor agonist that binds with high affinity to rat dopamine D4 and human dopamine D4.4 receptors (Ki=12.1 and 7.9 nM, respectively). In contrast to the dopamine D4 receptor agonists PD168077 and CP226269, A-412997 showed a better selectivity profile and no affinity <1000 nM for other dopamine receptors or any other proteins in a panel of seventy different receptors and… Expand
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