A 41 Exploring the heterogeneity of use - dependent sodium channel inhibitor drugs . I : Fast - vs . slow - inactivated state preference

Abstract

Certain drugs evidently exert their therapeutic effects via sodium channel inhibition: local anesthetics, class I antiarrhytmics and certain anticonvulsants. Novel sodium channel inhibitor compounds are actively investigated for other indications involving stroke, ischemia, various neurodegenerative conditions and pain syndroms. All these drugs cause… (More)

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