A 40-nucleotide repeat polymorphism in the human dopamine transporter gene

  title={A 40-nucleotide repeat polymorphism in the human dopamine transporter gene},
  author={Akira Sano and Keiji Kondoh and Yasuo Kakimoto and Ikuko Kondo},
  journal={Human Genetics},
A new polymorphic 40-nucleotide repeat in the human dopamine transporter gene is described. It may underlie individual differences in susceptibility to several neuropsychiatric diseases. 

Polymorphism of the Dopamine Transporter Gene in Populations of the Volga–Ural Region

Polymorphism at the dopamine transporter gene (DAT1) in populations of the Volga–Ural region was examined by means of polymerase chain reaction and statistically significant differences were revealed both between the populations belonging to one ethnic group and between the communities from different linguistic families.

Lack of association between dopamine transporter gene polymorphisms and delusional disorder.

Findings do not support relevant contributions of DAT gene variants to the pathogenesis of delusional disorder.

Dopamine transporter (DAT1) VNTR polymorphism in 12 Indian populations

The results demonstrate the variability of the DAT1 40-bp VNTR polymorphism in Indian populations and revealed a high similarity with East Asian populations.

Genetic Markers of Predisposition to Increased Anxiety

It was found that carriers of VA1+9+ genotype exhibit increased anxiety and significantly differed from individuals with other genotypes.

Lack of Association between Polymorphisms of the Dopamine Receptor D4 and Dopamine Transporter Genes and Personality Traits in a Korean Population

The associations between dopamine receptor D4 (DRD4) exon III and dopamine transporter (DAT1) polymorphisms and personality traits in a Korean population are investigated.

An interaction between the serotonin transporter promoter region and dopamine transporter polymorphisms contributes to harm avoidance and reward dependence traits in normal healthy subjects

It is suggested that the variants of 5-HTTLPR interacted with the DAT1 gene polymorphism to influence the HA and RD temperament subscales of TCI.

The 10-Repeat 3′-UTR VNTR Polymorphism in the SLC6A3 Gene May Confer Protection Against Parkinson’s Disease: A Meta-analysis

It is suggested that the SLC6A3 10R may be a protective factor in susceptibility to PD, which is found to be significantly different from PD in Asian populations.



Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA.

A rat dopamine transporter complementary DNA has been isolated with combined complementary DNA homology and expression approaches and Binding of the cocaine analog [3H]CFT to transfected COS cell membranes yields a pharmacological profile similar to that in striatal membranes.