A 40 kDa protein of the inner membrane is the mitochondrial calcium uniporter

  title={A 40 kDa protein of the inner membrane is the mitochondrial calcium uniporter},
  author={Diego De Stefani and Anna Raffaello and Enrico Teardo and Ildik{\`o} Szab{\`o} and Rosario Rizzuto},
Mitochondrial Ca2+ homeostasis has a key role in the regulation of aerobic metabolism and cell survival, but the molecular identity of the Ca2+ channel, the mitochondrial calcium uniporter, is still unknown. Here we have identified in silico a protein (named MCU) that shares tissue distribution with MICU1 (also known as CBARA1), a recently characterized uniporter regulator, is present in organisms in which mitochondrial Ca2+ uptake was demonstrated and whose sequence includes two transmembrane… CONTINUE READING
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