A 4-week randomized study of acetaminophen extended-release vs rofecoxib in knee osteoarthritis.

@article{Schnitzer2009A4R,
  title={A 4-week randomized study of acetaminophen extended-release vs rofecoxib in knee osteoarthritis.},
  author={Thomas J. Schnitzer and John R P Tesser and Kimberly M Cooper and Roy Altman},
  journal={Osteoarthritis and cartilage},
  year={2009},
  volume={17 1},
  pages={1-7}
}
OBJECTIVE To compare the safety and efficacy of acetaminophen extended-release (APAP ER) with rofecoxib for the management of pain associated with knee osteoarthritis (OA). METHODS Four hundred and three adult patients with moderate pain secondary to knee OA were randomized to receive APAP ER 1300 mg three times daily, rofecoxib 12.5mg once daily, or rofecoxib 25mg once daily. Primary end point was change from baseline at week 4 in the Western Ontario and McMaster Universities Osteoarthritis… CONTINUE READING