A 3D human neural cell culture system for modeling Alzheimer's disease

@article{Kim2015A3H,
  title={A 3D human neural cell culture system for modeling Alzheimer's disease},
  author={Young Hye Kim and Se Hoon Choi and Carla D'Avanzo and Matthias Hebisch and Christopher S Sliwinski and Enjana Bylykbashi and Kevin J. Washicosky and Justin B. Klee and Oliver Bruestle and Rudolph E. Tanzi and Doo Yeon Kim},
  journal={Nature Protocols},
  year={2015},
  volume={10},
  pages={985-1006}
}
Stem cell technologies have facilitated the development of human cellular disease models that can be used to study pathogenesis and test therapeutic candidates. These models hold promise for complex neurological diseases such as Alzheimer's disease (AD), because existing animal models have been unable to fully recapitulate all aspects of pathology. We recently reported the characterization of a novel 3D culture system that exhibits key events in AD pathogenesis, including extracellular… CONTINUE READING
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