A 3D human neural cell culture system for modeling Alzheimer's disease

  title={A 3D human neural cell culture system for modeling Alzheimer's disease},
  author={Young Hye Kim and Se Hoon Choi and Carla D'Avanzo and Matthias Hebisch and Christopher S Sliwinski and Enjana Bylykbashi and Kevin J. Washicosky and Justin B. Klee and Oliver Bruestle and Rudolph E. Tanzi and Doo Yeon Kim},
  journal={Nature Protocols},
Stem cell technologies have facilitated the development of human cellular disease models that can be used to study pathogenesis and test therapeutic candidates. These models hold promise for complex neurological diseases such as Alzheimer's disease (AD), because existing animal models have been unable to fully recapitulate all aspects of pathology. We recently reported the characterization of a novel 3D culture system that exhibits key events in AD pathogenesis, including extracellular… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 20 times over the past 90 days. VIEW TWEETS
37 Citations
44 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 37 extracted citations


Publications referenced by this paper.
Showing 1-10 of 44 references

A 3 D Alzheimer ’ s disease culture model and the induction of P 21activated kinase mediated sensing in iPSC derived neurons

  • D. Zhang
  • Biomaterials
  • 2014

A three - dimensional human neural cell culture model of Alzheimer ’ s disease

  • S. H. Choi
  • Nature
  • 2014

The familial Alzheimer ’ s disease APPV 717 I mutation alters APP processing and tau expression in iPSCderived neurons

  • C. R. Muratore
  • Hum . Mol . Genet .
  • 2014

Similar Papers

Loading similar papers…