A 3D cartilage - inflammatory cell culture system for the modeling of human osteoarthritis.

@article{Sun2011A3C,
  title={A 3D cartilage - inflammatory cell culture system for the modeling of human osteoarthritis.},
  author={Lin Sun and Xiuli Wang and David L Kaplan},
  journal={Biomaterials},
  year={2011},
  volume={32 24},
  pages={5581-9}
}
Inflammation plays a major role in the destruction of cartilage in osteoarthritis (OA), with the interaction of multiple mediators, immune cells, fibroblasts and chondrocytes. Current 2D studies in vitro with cell lines, as well as animal models, are limited in terms of providing insight into pathogenic mechanisms related to the human system. Hence, an in vitro human 3D cartilage tissue system was established to study the impact of inflammatory mediators on chondrocytes and matrices as an… CONTINUE READING