A 3D Heterotypic Multicellular Tumor Spheroid Assay Platform to Discriminate Drug Effects on Stroma versus Cancer Cells

@article{Weydert2019A3H,
  title={A 3D Heterotypic Multicellular Tumor Spheroid Assay Platform to Discriminate Drug Effects on Stroma versus Cancer Cells},
  author={Zoe Weydert and M. Lal-Nag and Lesley Mathews-Greiner and C. Thiel and H. Cordes and L. K{\"u}pfer and P. Guye and J. Kelm and M. Ferrer},
  journal={SLAS Discovery},
  year={2019},
  volume={25},
  pages={265 - 276}
}
Three-dimensional (3D) cell culture models are thought to mimic the physiological and pharmacological properties of tissues in vivo more accurately than two-dimensional cultures on plastic dishes. For the development of cancer therapies, 3D spheroid models are being created to reflect the complex histology and physiology of primary tumors with the hopes that drug responses will be more similar to and as predictive as those obtained in vivo. The effect of additional cell types in tumors, such as… Expand
High-throughput screening in multicellular spheroids for target discovery in the tumor microenvironment
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