A 31P-NMR study of some metabolic and functional effects of the inotropic agents epinephrine and ouabain, and the ionophore R02-2985 (X537A) in the isolated, perfused rat heart.

@article{Matthews1982A3S,
  title={A 31P-NMR study of some metabolic and functional effects of the inotropic agents epinephrine and ouabain, and the ionophore R02-2985 (X537A) in the isolated, perfused rat heart.},
  author={Paul M. Matthews and Sanders Williams and A M Seymour and Arnold A. Schwartz and Gunther Dube and David G. Gadian and George K. Radda},
  journal={Biochimica et biophysica acta},
  year={1982},
  volume={720 2},
  pages={
          163-71
        }
}
  • Paul M. Matthews, Sanders Williams, +4 authors George K. Radda
  • Published in Biochimica et biophysica acta 1982
  • Chemistry, Medicine
  • 1. Some metabolic effects of increased mechanical activity by the Langendorff-perfused rat heart have been characterized using 31P-NMR. Mechanical activity was increased by infusion of ouabain (0.9-7.0.10(-5) M), the ionophore R02-2985 (1.10(-5) M) or epinephrine (5.10(-8) M). 2. Similar metabolic changes accompanied infusion of each of the positive inotropic agents into hearts perfused with buffer containing 11 mM glucose as the substrate. In each case phosphocreatine concentrations decreased… CONTINUE READING

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