A 30-year journey from volume-regulated anion currents to molecular structure of the LRRC8 channel

@article{Strange2019A3J,
  title={A 30-year journey from volume-regulated anion currents to molecular structure of the LRRC8 channel},
  author={K. Strange and Toshiki Yamada and J. Denton},
  journal={The Journal of General Physiology},
  year={2019},
  volume={151},
  pages={100 - 117}
}
The swelling-activated anion channel VRAC has fascinated and frustrated physiologists since it was first described in 1988. Multiple laboratories have defined VRAC’s biophysical properties and have shown that it plays a central role in cell volume regulation and possibly other fundamental physiological processes. However, confusion and intense controversy surrounding the channel’s molecular identity greatly hindered progress in the field for >15 yr. A major breakthrough came in 2014 with the… Expand
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References

SHOWING 1-10 OF 161 REFERENCES
LRRC8 N termini influence pore properties and gating of volume-regulated anion channels (VRACs)
Identification of LRRC8 Heteromers as an Essential Component of the Volume-Regulated Anion Channel VRAC
Structure of a volume-regulated anion channel of the LRRC8 family
LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength
Structure of the human volume regulated anion channel
Comparative Effects of Chloride Channel Inhibitors on LRRC8/VRAC-Mediated Chloride Conductance
Intracellular and extracellular loops of LRRC8 are essential for volume-regulated anion channel function
...
1
2
3
4
5
...