A 3-synapse positive feedback loop regulates the excitability of an interneuron critical for sensitization in the leech.

@article{Crisp2006A3P,
  title={A 3-synapse positive feedback loop regulates the excitability of an interneuron critical for sensitization in the leech.},
  author={Kevin M. Crisp and Kenneth J. Muller},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 13},
  pages={3524-31}
}
Sensitization of reflexive shortening in the leech has been linked to serotonin (5-HT)-induced changes in the excitability of a single interneuron, the S cell. This neuron is necessary for sensitization and complete dishabituation of reflexive shortening, during which it contributes to the sensory-motor reflex. The S cell does not contain 5-HT, which is released primarily from the Retzius (R) cells, whose firing enhances S-cell excitability. Here, we show that the S cell excites the R cells… CONTINUE READING
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