A 3-O-sulfated heparan sulfate binding peptide preferentially targets herpes simplex virus 2-infected cells.

@article{Ali2012A3H,
  title={A 3-O-sulfated heparan sulfate binding peptide preferentially targets herpes simplex virus 2-infected cells.},
  author={Mohamed Mostafa Ali and Ghadah A. Karasneh and Min Jung Jarding and Vaibhav V. Tiwari and Deepak Shukla},
  journal={Journal of virology},
  year={2012},
  volume={86 12},
  pages={6434-43}
}
Herpes simplex virus 2 (HSV-2) is the primary cause of genital herpes, which is one of the most common sexually transmitted viral infections worldwide and a major cofactor for human immunodeficiency virus infection. The lack of an effective vaccine or treatment and the emergence of drug-resistant strains highlight the need for developing new antivirals for HSV-2. Here, we demonstrate that a low-molecular-weight peptide isolated against 3-O-sulfated heparan sulfate (3-OS HS) can efficiently… CONTINUE READING