A 3-Hydroxypropionate/4-Hydroxybutyrate Autotrophic Carbon Dioxide Assimilation Pathway in Archaea

@article{Berg2007A3A,
  title={A 3-Hydroxypropionate/4-Hydroxybutyrate Autotrophic Carbon Dioxide Assimilation Pathway in Archaea},
  author={I. Berg and Daniel Kockelkorn and Wolfgang Buckel and G. Fuchs},
  journal={Science},
  year={2007},
  volume={318},
  pages={1782 - 1786}
}
  • I. Berg, Daniel Kockelkorn, +1 author G. Fuchs
  • Published 2007
  • Medicine, Biology
  • Science
  • The assimilation of carbon dioxide (CO2) into organic material is quantitatively the most important biosynthetic process. We discovered that an autotrophic member of the archaeal order Sulfolobales, Metallosphaera sedula, fixed CO2 with acetyl–coenzyme A (acetyl-CoA)/propionyl-CoA carboxylase as the key carboxylating enzyme. In this system, one acetyl-CoA and two bicarbonate molecules were reductively converted via 3-hydroxypropionate to succinyl-CoA. This intermediate was reduced to 4… CONTINUE READING
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