A 3′-Untranslated Region (3′UTR) Induces Organ Adhesion by Regulating miR-199a* Functions

@article{Lee2009A3R,
  title={A 3′-Untranslated Region (3′UTR) Induces Organ Adhesion by Regulating miR-199a* Functions},
  author={Daniel Yenhong Lee and Tatiana A. Shatseva and Zina Jeyapalan and William Weidong Du and Zhaoqun Deng and Burton B. Yang},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={2541 - 2558}
}
Mature microRNAs (miRNAs) are single-stranded RNAs of 18-24 nucleotides that repress post-transcriptional gene expression. However, it is unknown whether the functions of mature miRNAs can be regulated. Here we report that expression of versican 3'UTR induces organ adhesion in transgenic mice by modulating miR-199a* activities. The study was initiated by the hypothesis that the non-coding 3'UTR plays a role in the regulation of miRNA function. Transgenic mice expressing a construct harboring… CONTINUE READING

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