A 3′ UTR transition within DEFB1 is associated with chronic and aggressive periodontitis

@article{Schaefer2010A3U,
  title={A 3′ UTR transition within DEFB1 is associated with chronic and aggressive periodontitis},
  author={Arne S. Schaefer and Gesa M. Richter and Michael Nothnagel and M L Laine and Andreas R{\"u}hling and Christine Sch{\"a}fer and N Cordes and Barbara Noack and Matthias Folwaczny and J{\"u}rgen Glas and Christof Doerfer and H Dommisch and Birte Groessner-Schreiber and S\oeren Jepsen and B. G. Loos and Stefan Schreiber},
  journal={Genes and Immunity},
  year={2010},
  volume={11},
  pages={45-54}
}
Periodontal diseases are complex inflammatory diseases and affect up to 20% of the worldwide population. An unbalanced reaction of the immune system toward microbial pathogens is considered as the key factor in the development of periodontitis. Defensins have a strong antimicrobial function and are important contributors of the immune system toward maintaining health. Here, we present the first systematic association study of DEFB1. Using a haplotype-tagging single nucleotide polymorphism (SNP… CONTINUE READING
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