A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional cigarettes.

@article{Kogel2014A2R,
  title={A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional cigarettes.},
  author={Ulrike Kogel and Walter K. Schlage and Florian Martin and Yang Xiang and Sam Ansari and Patrice Leroy and Patrick M Vanscheeuwijck and Stephan Gebel and Ansgar Buettner and Christoph Wyss and Marco Esposito and Julia Hoeng and Manuel C. Peitsch},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2014},
  volume={68},
  pages={204-17}
}
Towards a systems toxicology-based risk assessment, we investigated molecular perturbations accompanying histopathological changes in a 28-day rat inhalation study combining transcriptomics with classical histopathology. We demonstrated reduced biological activity of a prototypic modified risk tobacco product (pMRTP) compared with the reference research cigarette 3R4F. Rats were exposed to filtered air or to three concentrations of mainstream smoke (MS) from 3R4F, or to a high concentration of… CONTINUE READING
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