A 28-day oral toxicity study of echimidine and lasiocarpine in Wistar rats.

@article{Dalefield2016A2O,
  title={A 28-day oral toxicity study of echimidine and lasiocarpine in Wistar rats.},
  author={Rosalind R Dalefield and Michelle A Gosse and Utz Mueller},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2016},
  volume={81},
  pages={146-154}
}
Pyrrolizidine alkaloids (PAs) are a class of naturally-occurring plant toxins. Echimidine is one of the predominant PAs found in honeys produced in Australia and New Zealand. There is a lack of information on the oral toxicity of echimidine on which to base regulatory decisions concerning the risk to humans of these honeys. This GLP study was conducted to assess the subchronic dietary toxicity of echimidine to rats compared to that of lasiocarpine as a positive control. Wistar rats, 10/sex… CONTINUE READING
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