A 21st century revisionist's view at a turning point in enzymology.

@article{Nagel2009A2C,
  title={A 21st century revisionist's view at a turning point in enzymology.},
  author={Zachary D Nagel and Judith P Klinman},
  journal={Nature chemical biology},
  year={2009},
  volume={5 8},
  pages={543-50}
}
Despite the fact that the number of publications associated with the keyword 'enzyme' increases every year, the precise origin of enzyme catalysis has remained unresolved. Because of sustained intensive research efforts from an increasing number of laboratories, detailed information regarding the physics, chemistry and kinetics of enzymes is accumulating rapidly. The growing body of data contains many examples of kinetic behavior that are incompatible with a static view of enzyme catalysis. As… CONTINUE READING

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