A 2017 global update on folic acid-preventable spina bifida and anencephaly.

@article{Kancherla2018A2G,
  title={A 2017 global update on folic acid-preventable spina bifida and anencephaly.},
  author={Vijaya Kancherla and Kaustubh Wagh and Quentin W. Johnson and Godfrey P Oakley},
  journal={Birth defects research},
  year={2018},
  volume={110 14},
  pages={
          1139-1147
        }
}
BACKGROUND Spina bifida and anencephaly are largely preventable birth defects through mandatory folic acid fortification. Our objective was to estimate the proportion of folic acid-preventable spina bifida and anencephaly (FAP SBA) prevented worldwide through mandatory fortification of wheat and/or maize flour with folic acid during the year 2017. METHODS Using existing data, we identified countries with mandatory fortification policies that added at least 1.0 ppm folic acid to wheat and/or… 
A 2019 global update on folic acid‐preventable spina bifida and anencephaly
TLDR
The global proportion of folic acid‐preventable spina bifida and anencephaly prevented through mandatory folic Acid fortification of wheat and/or maize flour in 2019 is estimated.
Food Fortification With Folic Acid for Prevention of Spina Bifida and Anencephaly: The Need for a Paradigm Shift in Evidence Evaluation for Policy-Making
TLDR
A critical appraisal of published evidence supports the conclusion that food fortification with folic acid prevents folic-acid preventable spina bifida and anencephaly (FAP SBA), and should suffice to motivate political will to implement programs that will save thousands of lives each year.
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This audit confirms that over a generation, healthcare interventions have not succeeded in decreasing the number of pregnancies in Ireland complicated by NTD, and that revised strategies need to be developed and implemented.
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TLDR
It is concluded that national fortification with folic acid is not associated with a significant decrease in the prevalence of NTDs at the population level.
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TLDR
Current policy in the UK, Ireland and elsewhere in Europe for the prevention of NTD (based on periconceptional FA supplementation only), has proven to be largely ineffective and the evidence is addressed, as well as identifying the challenges in translating policy into practice.
Magnitude and Associated Factors of Neural Tube Defects in Ethiopia: A Systematic Review and Meta-Analysis
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The estimated pooled prevalence of neural tube defects among children in Ethiopia was 63.3 cases per 10 000 children, and previous family history and unplanned pregnancy were risk factors for Neural tube defects.
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TLDR
Implementation of mandatory fortification with folic acid offers governments a proven and rapid way to prevent FAP SBA-associated disability and mortality, and to help achieve health-related Sustainable Development Goals.
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TLDR
The pace of preventing these serious birth defects can be accelerated if more countries require fortification of both wheat and maize flour and if regulators set fortification levels high enough to increase a woman's daily average consumption of folic acid to 400 mcg.
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TLDR
An increasing prevention of FAPSBA in the world through folic acid fortification is estimated, yet the pace is slow, and there remains a lot of work to do in countries that do not implement mandatory fortification, which is key to achieving global and total prevention.
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TLDR
The Teratology Society has developed the following resolution to support mandatory fortification efforts and hope it can be used by fortification advocates worldwide to reduce the number of folic acidpreventable birth defects.
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TLDR
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TLDR
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TLDR
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TLDR
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