A 2.5-kilobase deletion containing a cluster of nine microRNAs in the latency-associated-transcript locus of the pseudorabies virus affects the host response of porcine trigeminal ganglia during established latency.

@article{Mahjoub2015A2D,
  title={A 2.5-kilobase deletion containing a cluster of nine microRNAs in the latency-associated-transcript locus of the pseudorabies virus affects the host response of porcine trigeminal ganglia during established latency.},
  author={Nada Mahjoub and Sophie Dhorne-Pollet and Walter Fuchs and Marie-Laure Endale Ahanda and Elke D. Lange and Barbara G. Klupp and Anoop Arya and Jane E. Loveland and François Lef{\`e}vre and Thomas C Mettenleiter and Elisabetta Giuffra},
  journal={Journal of virology},
  year={2015},
  volume={89 1},
  pages={428-42}
}
UNLABELLED The alphaherpesvirus pseudorabies virus (PrV) establishes latency primarily in neurons of trigeminal ganglia when only the transcription of the latency-associated transcript (LAT) locus is detected. Eleven microRNAs (miRNAs) cluster within the LAT, suggesting a role in establishment and/or maintenance of latency. We generated a mutant (M) PrV deleted of nine miRNA genes which displayed properties that were almost identical to those of the parental PrV wild type (WT) during… CONTINUE READING
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