A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia.

@article{Sinkus2009A2P,
  title={A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia.},
  author={Melissa L Sinkus and Michael J. Y. Lee and Judith Gault and Judith Logel and Margaret Short and Robert Freedman and Susan L. Christian and Jennifer Rose Lyon and Sherry Leonard},
  journal={Brain research},
  year={2009},
  volume={1291},
  pages={1-11}
}
Multiple genetic linkage studies support the hypothesis that the 15q13-14 chromosomal region contributes to the etiology of schizophrenia. Among the putative candidate genes in this area are the alpha7 nicotinic acetylcholine receptor gene (CHRNA7) and its partial duplication, CHRFAM7A. A large chromosomal segment including the CHRFAM7A gene locus, but not the CHRNA7 locus, is deleted in some individuals. The CHRFAM7A gene contains a polymorphism consisting of a 2 base pair (2 bp) deletion at… CONTINUE READING

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