A -174G/C polymorphism of the interleukin-6 gene in patients with lacunar infarction

  title={A -174G/C polymorphism of the interleukin-6 gene in patients with lacunar infarction},
  author={Mari{\'a}n Revilla and Vı́ctor Obach and {\'A}lvaro Cervera and Antoni Davalos and {\'A}ngel Chamorro},
  journal={Neuroscience Letters},
Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a central role in the pathogenesis of stroke. A base pair substitution -174G/C in the promoter region of the IL-6 gene regulates IL-6 gene expression. We compared the prevalence of this polymorphism in patients with lacunar stroke and in an age- and sex-matched cohort of asymptomatic controls. Eighty-two patients with lacunar stroke and 82 asymptomatic controls were prospectively assessed and genotyped for the -174G/C polymorphism in the… CONTINUE READING


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