A 15N nuclear magnetic resonance study of the biosynthesis of quinoxaline antibiotics.

Abstract

Uniformly 15N-labelled triostin A and echinomycin have been prepared by growing the producing organisms on enriched media and their 15N nuclear magnetic resonance spectra partially assigned by a combination of nuclear Overhauser effect and scalar coupling constant measurements. Selective feeding experiments using unlabelled L-tryptophan-supplemented media have shown that N-1 and N-4 of the quinoxaline rings have their origins in the indole and amino groups of tryptophan, respectively.

Cite this paper

@article{Reid1984A1N, title={A 15N nuclear magnetic resonance study of the biosynthesis of quinoxaline antibiotics.}, author={David G Reid and David M. Doddrell and Dudley H. Williams and Keith R. Fox}, journal={Biochimica et biophysica acta}, year={1984}, volume={798 1}, pages={111-4} }