A 150-kDa glycoprotein isolated from Solanum nigrum L. has cytotoxic and apoptotic effects by inhibiting the effects of protein kinase C alpha, nuclear factor-kappa B and inducible nitric oxide in HCT-116 cells

@article{Lee2004A1G,
  title={A 150-kDa glycoprotein isolated from Solanum nigrum L. has cytotoxic and apoptotic effects by inhibiting the effects of protein kinase C alpha, nuclear factor-kappa B and inducible nitric oxide in HCT-116 cells},
  author={S Y Lee and Phil-Sun Oh and Jeong-Hyeon Ko and Kwang Lim and Kyoungmook Lim},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2004},
  volume={54},
  pages={562-572}
}
This study was carried out to investigate the anticancer effects of a 150-kDa glycoprotein isolated from Solanum nigrum L. (SNL glycoprotein) on spontaneously and experimentally induced tumor promotion in HCT-116 cells. For spontaneously induced tumor promotion, we evaluated the cytotoxic and apoptotic effects in HCT-116 cells using 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide (MTT), DNA fragmentation, and H33342 and ethidium bromide staining assays. SNL glycoprotein had… CONTINUE READING
Highly Cited
This paper has 35 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Antiproliferative Effect of Solanum nigrum on Human Leukemic Cell Lines

Indian journal of pharmaceutical sciences • 2012
View 2 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 46 references

An epitope residing in carbohydrate chains of a sea squirt antigen termed Gi-rep.

The Journal of allergy and clinical immunology • 1987
View 10 Excerpts
Highly Influenced

Antioxidative effects of glycoprotein isolated from Solanum nigrum Linne on oxygen radicals and its cytotoxic effects on the MCF-7 cell

SJ Lee, KT Lim
J Food Sci • 2003
View 3 Excerpts

Antioxidative and antimicrobial effects of glycoprotein isolated from Solanum nigrum Linne

KT Lim, KS Heo, YO Son
Food Sci Biotechnol • 2002
View 2 Excerpts