A 14-3-3γ dimer-based scaffold bridges CtBP1-S/BARS to PI(4)KIIIβ to regulate post-Golgi carrier formation

@article{Valente2012A1D,
  title={A 14-3-3γ dimer-based scaffold bridges CtBP1-S/BARS to PI(4)KIIIβ to regulate post-Golgi carrier formation},
  author={Carmen Valente and Gabriele Turacchio and Stefania Mariggi{\`o} and Alessandro Pagliuso and Renato Gaibisso and Giuseppe Di Tullio and Michele Santoro and Fabio Formiggini and Stefania Span{\`o} and Daniele Piccini and Roman S. Polishchuk and Antonino Colanzi and Alberto Luini and Daniela Corda},
  journal={Nature Cell Biology},
  year={2012},
  volume={14},
  pages={343-354}
}
Large pleiomorphic carriers leave the Golgi complex for the plasma membrane by en bloc extrusion of specialized tubular domains, which then undergo fission. Several components of the underlying molecular machinery have been identified, including those involved in the budding/initiation of tubular carrier precursors (for example, the phosphoinositide kinase PI(4)KIIIβ, the GTPase ARF, and FAPP2), and in the fission of these precursors (for example, PKD, CtBP1-S/BARS). However, how these proteins… CONTINUE READING