A 12-week, double-blind, placebo-controlled trial of donepezil adjunctive treatment to risperidone in chronic and stable schizophrenia

@article{Akhondzadeh2008A1D,
  title={A 12-week, double-blind, placebo-controlled trial of donepezil adjunctive treatment to risperidone in chronic and stable schizophrenia},
  author={Shahin Akhondzadeh and Maryam Gerami and Maryam Noroozian and Narges Karamghadiri and Sams-Ali Rezazadeh},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2008},
  volume={32},
  pages={1810-1815}
}
There is considerable incentive to develop new treatment strategies that effectively target cognitive deficits in schizophrenia. One of the theoretically promising novel treatment candidates is acetylcholinesterase inhibitors that increase the synaptic levels of cholinergic, nicotinic, and muscarinic receptor activity. The purpose of this study was to assess the efficacy of donepezil as an adjuvant agent in the treatment of chronic schizophrenia in particular for cognitive impairments. This… CONTINUE READING

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