A 12-month treatment of severe psoriasis with acitretin: results of a Canadian open multicenter study.

@article{Murray1991A1T,
  title={A 12-month treatment of severe psoriasis with acitretin: results of a Canadian open multicenter study.},
  author={H E Murray and A W Anhalt and Richard Lessard and R K Schacter and J Barrie Ross and William D. P. Stewart and Justin M Geiger},
  journal={Journal of the American Academy of Dermatology},
  year={1991},
  volume={24 4},
  pages={598-602}
}
Both etretinate and its principal metabolite, acitretin, are efficacious in the treatment of psoriasis. Because patients with severe psoriasis often require chronic therapy, this study was undertaken to determine the efficacy, tolerability, and safety of acitretin in patients on continuous treatment for 12 months. The initial daily dose of 50 mg was taken for 4 weeks. Thereafter the dose was increased or decreased by 10 mg at monthly intervals (10 to 70 mg) to produce the optimal response with… CONTINUE READING

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