A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion.

@article{Ghiso1992A1C,
  title={A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion.},
  author={Jorge Ghiso and Agueda Rostagno and J E Gardella and L H Liem and Peter D. Gorevic and Blas Frangione},
  journal={The Biochemical journal},
  year={1992},
  volume={288 ( Pt 3)},
  pages={1053-9}
}
Amyloid beta (A beta), the major constituent of the fibrils composing senile plaques and vascular amyloid deposits in Alzheimer's disease (AD) and related disorders, is a 39-42-residue self-aggregating degradation peptide of a larger multidomain membrane glycoprotein designated amyloid precursor protein (APP). An array of biological functions has been assigned to different APP domains, including growth regulation, neurotoxicity, inhibitory activity of serine proteinases and promotion of cell… CONTINUE READING

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